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Is nicotine safe with propranolol?

Is nicotine safe with propranolol? Notes for Professionals: Advise patients to avoid smoking tobacco while taking propranolol. Smoking tobacco has been observed to decrease propranolol exposure by approximately 50% and may decrease efficacy. The apparent body clearance (ABC) of propranolol in the smoking group was significantly greater than in the non-smoking group (p less than

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