How long does it take for SAM-e to work for depression?
Taking SAM-e with L-methylfolate can reduce homocysteine accumulation. Full antidepressant response may take 4–6 weeks, similar to standard antidepressants. SAM-e should be continued for at least 6–12 months. Other research suggests that taking 800 milligrams (mg) of SAM-e each day in combination with an antidepressant may improve depression symptoms. A 2020 study indicates that taking larger doses of SAM-e, up to 3,200 mg per day, may be more effective for treating symptoms of depression.
What to avoid when taking SAM-e?
Patients taking selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, or other drugs that affect serotonin levels should avoid taking SAM-e without the supervision of a physician due to case reports of mania and serotonin syndrome, a serious condition, or . Taking supplemental SAM-e may increase the turnover of serotonin in the brain. It may also increase dopamine activity and inhibit the reuptake of norepinephrine. Because these neurotransmitters can play a role in depression, SAM-e may reduce depression symptoms in some people.