What is the indication of caffeine?
People most commonly use caffeine for mental alertness, headache, migraine, athletic performance, memory, and obesity. It is also used for asthma, gallbladder disease, ADHD, low blood pressure, depression, and many other conditions, but there is no good scientific evidence to support most of these other uses. Low to moderate doses of caffeine (50–300 mg) may cause increased alertness, energy, and ability to concentrate, while higher doses may have negative effects such as anxiety, restlessness, insomnia, and increased heart rate.Caffeine is a stimulant, which means it increases activity in your brain and nervous system. It also increases the circulation of chemicals such as cortisol and adrenaline in the body. In small doses, caffeine can make you feel refreshed and focused.How does caffeine affect blood pressure? Caffeine may cause a brief rise in your blood pressure, even if you don’t have high blood pressure. This short-term spike in blood pressure happens mainly in people who don’t drink caffeine often, rather than in those who do.Caffeine can worsen existing anxiety What it can do is amplify your existing symptoms — especially increased heart rate and blood pressure — and make them feel more intense. People who experience panic attacks may also want to be cautious about excessive caffeine consumption.
What is the mode of action of caffeine?
Caffeine increases intracellular concentrations of cyclic adenosine monophosphate (cAMP) by inhibiting phosphodiesterase enzymes in skeletal muscle and adipose tissues. These actions promote lipolysis via the activation of hormone-sensitive lipases with the release of free fatty acids and glycerol. This is because caffeine narrows or constricts the blood vessels in your brain. Without caffeine, the vessels widen back out, which triggers a sharp headache. If you banish caffeine, expect two to nine days of headaches, with the most intensity on days one and two. You may also notice rebound fatigue.Caffeine is a stimulant drug, which means it speeds up the messages travelling between the brain and the body.In the brain, caffeine acts as an antagonist of adenosine A1 and A2A receptors, leading to hyperexcitability of the central nervous system [3, 4]. This induces acute effects in diverse domains, such as physical endurance [1, 5], vigilance, dexterity [6], mood [7, 8], memory [9], and cognitive function [1, 8, 10].Caffeine can trigger a headache. And because caffeine narrows the blood vessels that surround the brain, when consumption is stopped, the blood vessels enlarge. This causes an increase in blood flow around the brain and pressures surrounding nerves. This can then trigger what is known as a caffeine withdrawal headache.
When is caffeine citrate given?
Caffeine citrate injection is used to treat short-term apnea of prematurity when premature babies (infants between 28 and 32 weeks gestational age) stop breathing. Apnea of prematurity is caused by the baby’s breathing centers not being fully developed. Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies.Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection. The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999.Caffeine citrate is a central stimulant agent: it inhibits adenosine receptors, affects release, turnover, and levels of several other transmitters, including biogenic amines (dopamine, noradrenalin, serotonin), acetylcholine, and excitatory and inhibitory amino acids.Caffeine citrateproduct ingredient for caffeine caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness.Caffeine is a central nervous system stimulant and seizures have been reported in cases of caffeine overdose. Extreme caution must be exercised if caffeine citrate is used in newborns with seizure disorders.
What is the pharmacological action of caffeine citrate?
In summary, caffeine citrate is an important therapeutic agent in the management of apnea of prematurity. Its mechanism of action primarily involves the blockade of adenosine receptors, leading to increased neuronal activity and enhanced respiratory function. Description. Caffeine citrate injection is used to treat short-term apnea of prematurity when premature babies (infants between 28 and 32 weeks gestational age) stop breathing. Apnea of prematurity is caused by the baby’s breathing centers not being fully developed.Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.Caffeine is a stimulant, which means it increases activity in your brain and nervous system. It also increases the circulation of chemicals such as cortisol and adrenaline in the body. In small doses, caffeine can make you feel refreshed and focused.Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to Theophylline and Theobromine.
How to give IV caffeine citrate?
The recommended dose regimen in previously untreated infants is a loading dose of 20 mg caffeine citrate per kg body weight administered by slow intravenous infusion over 30 minutes, using a syringe infusion pump or other metered infusion device. IV caffeine citrate solutions can be used orally with or without dilution. Draw up 2mL (40 mg) of caffeine citrate and add 6mL water for injection to make a final volume of 8 mL with a concentration of 5 mg/mL.