Does SAM-e really help depression?
Research on SAMe use for specific conditions shows: Depression. While research has shown that SAMe has a positive effect in treating depression, most studies weren’t well designed and included a small number of people. Depression is among the most treatable of mental disorders. Between 70% and 90% percent of people with depression eventually respond well to treatment.The suggested treatments included dietary measures, exercise, distraction, travel, cleanses, bloodletting, herbal remedies, marriage and music therapy.
How long does SAM-e take to work for depression?
Dosage & Interactions Start with 1 tablet per day. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. Clinical studies indicate that benefits are most likely evident after 7–14 days of supplementation. For depression, many study participants have started at 400-600 milligrams daily. For osteoarthritis, 600-1,200 milligrams of SAM-e daily, divided into three doses, is common. Ask your doctor for advice. Sometimes, the dose of SAM-e is raised gradually over a few weeks.
Does SAM-e increase dopamine or serotonin?
Taking supplemental SAM-e may increase the turnover of serotonin in the brain. It may also increase dopamine activity and inhibit the reuptake of norepinephrine. Because these neurotransmitters can play a role in depression, SAM-e may reduce depression symptoms in some people. SAM-e and caffeine are two popular substances people use to boost their mood and energy. SAM-e, short for S-adenosyl methionine, is a compound our bodies make naturally. It plays a key role in many bodily functions. Caffeine, on the other hand, is a stimulant most of us know well from our morning coffee or tea.